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desvenlafaxine will increase the degree or effect of codeine by influencing hepatic enzyme CYP2D6 metabolism. Use Caution/Check. Desvenlafaxine inhibits CYP2D6; with bigger desvenlafaxine doses (ie, four hundred mg) lessen the CYP2D6 substrate dose by approximately 50%; no dosage adjustment desired with desvenlafaxine doses seven consecutive days r